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SNX-2112

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SI-5761

SNX-2112, >98% (HPLC)

CAS No. : [908112-43-6]

MDL No. : MFCD16038907

Synonyms : PF-04928473

IUPAC Name : 4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide

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Chemical Properites
Mol. Formula :
C23H27F3N4O3
Mol. Weight :
464.49
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : SNX-2112 is a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

References : Chandarlapaty S. et al, Clin Cancer Res., 14(1), 240-248, 2008; Okawa Y. et al.: Blood, 113(4), 846-855, 2009; Chinn D. C. et al.: Pediatr Blood Cancer., 58(6), 885-890, 2012; Liu K. S. et al.: Cancer Lett., 318(2), 180-188, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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