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Sobetirome

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SI-7069

Sobetirome, >98% (HPLC)

CAS No. : [211110-63-3]

Synonyms : QRX-431; GC-1

IUPAC Name : 2-(4-(4-Hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid

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Chemical Properites
Mol. Formula :
C20H24O4
Mol. Weight :
328.41
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Sobetirome functions as a TRβ‑specific agonist with strong affinity for the TRβ‑1 isoform (EC50 = 0.16 μM). Its receptor selectivity makes it a valuable tool for probing TRβ‑dependent signaling pathways.

References :
Gierach I. et al.: FEBS Open Bio., 2, 247-53, 2012; Johansson L. et al.: Proc. Natl. Acad. Sci. U S A., 102(29), 10297-302, 2005; Villicev C. M. et al.: J. Endocrinol., 193(1), 21-9, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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