Sofosbuvir-13C, d3 (mixture of diastereomers)

SL-1087

Sofosbuvir-¹³C, d₃ (mixture of diastereomers), >98% (HPLC)

Isotopic Purity : 99 atom % D and 13C

CAS No. : [1256490-44-4]

MDL No. : MFCD28900730

Related CAS No. : [1190307-88-0] of the unlabelled compound

Synonyms : GS-7977-¹³C, d₃; PSI-7977-¹³C, d₃

IUPAC Name : Isopropyl ((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-(methyl-¹³C-d₃)tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

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Applications : It is a double labelled analog of Sofosbuvir, which is a potent inhibitor of hepatitis C virus (HCV). It has showed promising therapeutic activity against hepatitis C virus. This can be used as an internal standard for the quantification of Sofosbuvir by GC- or LC-mass spectrometry.

References : Chun B-K. et al.: Nucleosides, Nucleotides and Nucleic Acids,30, 886, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.