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Sofosbuvir D-alaninate (R,S)-isomer

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Sofosbuvir D-alaninate (R,S)-isomer, >98%

CAS No. : [1496552-28-3]

IUPAC Name : Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate

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5MGRequest A Quote
In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C22H29FN3O9P
Mol. Weight :
529.46
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Sofosbuvir, which is a novel nucleotide NS5B polymerase inhibitor. Sofosbuvir has showed promising therapeutic activity against hepatitis C virus.

References : Gentile I. et al.: Curr. Med. Chem., 20(30), 3733, 2013; Murakami E. et al.: J. Biol Chem., 285(45), 34337-47, 2010; Lam A. M. et al.: Antimicrob Agents Chemother., 56(6), 3359-68, 2012; Sofia M. J. et al.: J Med Chem., 53(19), 7202-18, 2010; Zhang X, et al.: Eur. J. Med Chem.,143, 1053-1065, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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