Sorafenib 2-chloro isomer

SL-9909

Sorafenib 2-chloro isomer, >98%

CAS No. : [1431697-81-2]

Synonyms : 4-Deschloro-2-chloro sorafenib; Sorafenib related compound; Sorafenib 2-chloro analog; Sorafenib impurity H

IUPAC Name : 4-(4-(3-(2-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

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Applications : This is an analog or impurity of Sorafenib, which is a new small molecule multi-kinase inhibitor for the treatment of patients with advanced renal cell carcinoma. It works by blocking the action of an abnormal protein that signals cancer cells to multiply and helps stop the spread of cancer cells.

References : Wilhelm S. M. et al.: Cancer Res., 64(19), 7099-109, 2004; El-Ashmawy N. E. et al.: Clin Exp Med., 17(2),185-191, 2017; Jin W. et al.: Oncol Rep., 37(1), 273-280, 2017; Li M. et al.: Br. J. Cancer 117(7), 974-983, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.