SOS1-IN-14

SI-7180

SOS1-IN-14, >98% (HPLC)

CAS No. : [2793405-20-4]

IUPAC Name : 1-((S)-12-(((R)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethyl)amino)-10-methyl-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1',2':4,5][1,4]oxazepino[3,2-g]quinazoline-3-carbonyl)cyclopropane-1-carbonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This potently inhibits SOS1 (IC₅₀= 3.9 nM), shows oral activity, and undergoes P‑gp–mediated intestinal efflux. It is widely used to study KRAS‑mutant cancers and displays greater antitumor potency than BI‑3406.

References : He H. et al.: J .Med. Chem., 65(19), 13158-13171, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.