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Sotuletinib

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SI-5691

Sotuletinib, >98% (HPLC)

CAS No. : [953769-46-5]

MDL No. : MFCD28142668

Synonyms : BLZ945

IUPAC Name : 4-((2-(((1R,2R)-2-Hydroxycyclohexyl)amino)benzo[d]thiazol-6-yl)oxy)-N-methylpicolinamide

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Chemical Properites
Mol. Formula :
C20H22N4O3S
Mol. Weight :
398.48
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Sotuletinib is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs.

References : Pyonteck S. M. et al.: Nat Med., 19(10), 1264-72, 2013; Strachan D. C. et al.: Oncoimmunology 2(12), e26968, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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