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SL-9922

Sparsentan, >98%

CAS No. : [254740-64-2]

Synonyms : DARA-a; RE-021

IUPAC Name : 4'-((2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide

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Chemical Properites
Mol. Formula :
C32H40N4O5S
Mol. Weight :
592.75
Appearance :
White to Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : Sparsentan is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively.It is used to treat primary immunoglobulin A (IgA) nephropathy.

References : Murugesan N. et al.: J. Med Chem., 48(1), 171-179, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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