Spebrutinib

SI-5190

Spebrutinib, >98% (HPLC)

CAS No. : [1202757-89-8]

MDL No. : MFCD25976876

Synonyms : AVL-292; CC-292

IUPAC Name : N-(3-((5-Fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
250MG	95.00		In Stock	Estimated to ship on 20 September 2026
1G	235.00		In Stock	Estimated to ship on 20 September 2026
5G	955.00		In Stock	Estimated to ship on 20 September 2026
10G	1855.00		In Stock	Estimated to ship on 20 September 2026

Applications : Spebrutinib is a covalent, orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM, displaying at least 1400-fold selectivity over the other kinases assayed. Spebrutinib was under clinical development for the treatment of rheumatoid arthritis (phase II) and B-cell Lymphoma (phase I).

References : Evans E. K et al. J. Pharmacol Exp Ther., 346(2), 219-28, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.