SPR inhibitor 3

SI-7692

SPR inhibitor 3, >98% (HPLC)

CAS No. : [1292285-54-1]

Synonyms : SPRi3

IUPAC Name : N-(2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl)-2-methoxyacetamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : This potently targets sepiapterin reductase, showing strong biochemical inhibition (IC₅₀ = 74 nM) and suppressing biopterin production in cell‑based assays (IC₅₀= 5.2 µM). Through BH₄ reduction, SPRi3 mitigates neuropathic and inflammatory pain, making it a valuable tool for probing SPR‑mediated nociceptive pathways.

References : Latremoliere A. et al.: Neuron, 86(6), 1393-406, 2015; Cronin S. J. F. et al.: Nature, 563(7732), 564-568, 2018; Haruki H. et al.: J. Biol. Chem., 291(2), 652-7, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.