SR-4835

SI-7823

SR-4835, >98% (HPLC)

CAS No. : [2387704-62-1]

IUPAC Name : N-((5,6-Dichloro-1H-benzo[d]imidazol-2-yl)methyl)-9-(1-methyl-1H-pyrazol-4-yl)-2-morpholino-9H-purin-6-amine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : SR‑4835 selectively and potently inhibits CDK12 (IC₅₀= 99 nM; Kd = 98 nM) and CDK13 (Kd = 4.9 nM) through ATP‑competitive binding. It enhances the efficacy of DNA‑damaging chemotherapy and PARP inhibition and triggers pronounced TNBC cell death, making it a valuable tool for probing CDK12/13‑regulated DNA‑repair pathways.

References : Quereda V. et al.: Cancer Cell, S1535-6108(19), 30424-6, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.