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STAT3-IN-13

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SI-7041

STAT3-IN-13, >98% (HPLC)

CAS No. : [2248552-86-3]

IUPAC Name : 3-Cyano-N-(4-methoxyphenyl)-2-(1-methyl-1H-pyrazole-4-carboxamido)-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxamide

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Chemical Properites
Mol. Formula :
C21H20N6O3S
Mol. Weight :
436.49
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This potently inhibits STAT3 by binding its SH2 domain (K_D = 0.46 µM), thereby reducing STAT3 Y705 phosphorylation and downstream gene expression. It induces apoptosis and inhibits proliferation in vitro, while effectively limiting tumor growth and metastasis in vivo.

References :
Jin W. et al.: J. Med. Chem., 65(9), 6710-6728, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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