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Suplatast dimer impurity 1

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Suplatast dimer impurity 1, >98%

IUPAC Name : (((((2-Hydroxypropane-1,3-diyl)bis(oxy))bis(4,1-phenylene))bis(azanediyl))bis(3-oxopropane-3,1-diyl))bis(dimethylsulfonium) 4-methylbenzenesulfonate; 2-Hydroxypropylene-1,3-dioxy bis-[[2-(4-phenylcarbamoyl)ethyl]-dimethylsulfonium]-di-p-toulene sulfonate

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Chemical Properites
Mol. Formula :
C25H36N2O5S2 • 2C7H7O3S
Mol. Weight :
851.07
Appearance :
Off-white solid (hygroscopic)
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Suplatast tosilate, which is an orally administered inhibitor of Th2 cytokines, capable of suppressing both IL-4 and IL-5 production from Th2 cells as well as inhibiting IgE synthesis. Suplatast tosilate functions as an anti-allergic agent and exhibits antiasthmatic, anti-inflammatory, and antifibrotic properties.

References : Yanagihara Y. et al.: Jpn. J. Pharmacol., 61(1), 31-9, 1993; Zhao G. D. et al.: Int Arch Allergy Immunol., 121(2),116-22, 2000; Kurokawa M. et al.: Mediators Inflamm., 10(6), 333-337, 2001; Furonaka M. J. Pharmacol Exp Ther., 328(1), 55-61, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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