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Suzetrigine

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SL-11866

Suzetrigine, >98%

CAS No. : [2649467-58-1]

Synonyms : VX-548

IUPAC Name : 4-((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamido)picolinamide

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Chemical Properites
Mol. Formula :
C21H20F5N3O4
Mol. Weight :
473.40
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Suzetrigine is an orally administered, highly selective inhibitor of NaV1.8 that functions as an analgesic agent. In addition, Suzetrigine acts as a blocker of sodium channel protein type 10 subunit alpha. This compound shows significant potential for research related to the management of acute pain following abdominoplasty and bunionectomy procedures.

References : Jones J. et al.: N.Engl J. Med., 389(5), 393-405, 2023; Zhang H. et al.: Biomed Chromatogr., 38(7), e5907, 2024; Yu G. et al.: Biopharm Drug Dispos., 45(2), 107-114, 2024; Qin H. et al.: Eur. J. Med. Chem., 254, 115371, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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