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Synta-66

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SI-6871

Synta-66, >98% (HPLC)

CAS No. : [835904-51-3]

IUPAC Name : N-(2',5'-Dimethoxy-[1,1'-biphenyl]-4-yl)-3-fluoroisonicotinamide

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Chemical Properites
Mol. Formula :
C20H17FN2O3
Mol. Weight :
352.37
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Synta-66 blocks Orai‑mediated SOCE, inhibiting the pore‑forming CRAC channel complex. Its ability to modulate Ca²⁺ entry makes it a valuable tool for studying dysregulated calcium signaling in neurological disorders.

References : Molnar T. et al.: J Neurosci, 36(11), 3184-98, 2016; van Kruchten R. et al.: Arterioscler Thromb Vasc Biol., 32(7):1717-23; 2012; Wajdner HE, et al.; Physiol. Rep., (5); 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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