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T4-Lactic acid

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T4-Lactic acid, >98%

CAS No. : [7069-47-8]

Synonyms : 3,5,3′,5′-Tetraiodothyrolactic acid; α-Hydroxy-4-(4-hydroxy-3,5-diiodophenoxy)-3,5- diiodobenzene propanoic acid

IUPAC Name : 2-Hydroxy-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid

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Chemical Properites
Mol. Formula :
C15H10I4O5
Mol. Weight :
777.86
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Levothyroxine, which is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

References : Arici M. et al.: Endocr J. 65(3), 317, 2018; Corriveau S. et al.: J. Clin Transl Endocrinol., 2(4),144, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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