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Tagtociclib hydrate

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SI-7233

Tagtociclib hydrate, >98% (HPLC)

CAS No. : [2733575-91-0]

Synonyms : PF-07104091 hydrate

IUPAC Name : (1R,3S)-3-(3-(3-(Methoxymethyl)-1-methyl-1H-pyrazole-5-carboxamido)-1H-pyrazol-5-yl)cyclopentyl isopropylcarbamate hydrate

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Chemical Properites
Mol. Formula :
C19H28N6O4 • H2O
Mol. Weight :
422.49
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Tagtociclib hydrate is a potent and selective inhibitor of CDK2/cyclin E1 and GSK3β, with Kᵢ values of 1.16 nM and 537.81 nM, respectively. It exhibits antitumor activity in cyclin E1‑amplified cancers.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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