TAK-243

SI-6250

TAK-243, >98% (HPLC)

CAS No. : [1450833-55-2]

Synonyms : MLN-7243

IUPAC Name : ((1R,2R,3S,4R)-2,3-Dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)methyl sulfamate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : TAK‑243 selectively inhibits UBA1 with nanomolar potency (IC₅₀ = 1 nM), resulting in loss of ubiquitin conjugation and broad impairment of ubiquitination pathways. The resulting ER stress and NF‑κB blockade drive apoptotic cell death, positioning TAK‑243 as a key tool compound for probing ubiquitin‑dependent signaling in cancer biology.

References : Hyer M. L. et al.: Nat. Med., 24(2), 186-193, 2018; Best S. R. et al.: Blood, 130, 1533, 2017; Barghout H. S. et al., Blood, 130, 814, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.