Taletrectinib

SI-7368

Taletrectinib, >98% (HPLC)

CAS No. : [1505515-69-4]

Synonyms : DS-6051b; AB-106; IBI-344

IUPAC Name : 3-(4-((R)-2-Aminopropoxy)phenyl)-N-((R)-1-(3-fluorophenyl)ethyl)imidazo[1,2-b]pyridazin-6-amine adipate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Taletrectinib is a potent, orally active ROS1/NTRK inhibitor with IC₅₀values of 0.207 nM (ROS1), 0.622 nM (NTRK1), 2.28 nM (NTRK2), and 0.98 nM (NTRK3). In addition to its strong activity against wild‑type kinases, it inhibits ROS1 G2032R and other Crizotinib‑resistant ROS1 mutants, making it valuable for investigating resistance mechanisms in ROS1‑ and NTRK‑driven malignancies.

References : Katayama R. et al.: Nat. Commun., 10(1), 3604, 2019; Fujiwara Y. et al.: Oncotarget, 9(34), 23729-23737, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.