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Taniborbactam hydrochloride

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SI-5497

Taniborbactam hydrochloride, >98% (HPLC)

CAS No. : [2244235-49-0]

Synonyms : VNRX-5133 hydrochloride

IUPAC Name : (R)-3-(2-((1r,4R)-4-((2-Aminoethyl)amino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid dihydrochloride

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Chemical Properites
Mol. Formula :
C19H28BN3O5. 2HCl
Mol. Weight :
462.18
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Taniborbactam hydrochloride is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactamhydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria.

References : Krajnc A. et al.: J. Med Chem., 62(18), 8544-8556, 2019; Liu B. et al.: J. Med Chem., 63(6), 2789-2801, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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