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TBI-223

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SI-6233

TBI-223, >98% (HPLC)

CAS No. : [2071265-08-0]

IUPAC Name : Methyl (S)-((3-(3-fluoro-4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)carbamate

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Chemical Properites
Mol. Formula :
C17H20FN3O5
Mol. Weight :
365.36
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : TBI‑223 is an oral oxazolidinone antibiotic active against M. tuberculosis and effective in multiple MRSA mouse infection models. It inhibits mitochondrial protein synthesis in HepG2 cells (IC50 = 68 µg/mL) and serves as a valuable tool compound for studying drug‑resistant TB and Gram‑positive pathogens.

References : Negatu D. A. et al.: Antimicrob. Agents Chemother, 67(4), e0165522, 2023; Gordon O. et al.: Microbiol. Spectr., 10(5), e0245121, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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