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SL-9964

Tegoprazan, >98%

CAS No. : [942195-55-3]

Synonyms : RQ-00000004; CJ-12420

IUPAC Name : (S)-4-((5,7-Difluorochroman-4-yl)oxy)-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide

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Chemical Properites
Mol. Formula :
C20H19F2N3O3
Mol. Weight :
387.39
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : Tegoprazan is a potassium-competitive acid blocker that acts as a reversible, orally active, and selective inhibitor of gastric H+/K+-ATPase. It reduces gastric acid secretion and motility in porcine, canine, and human H+/K+-ATPase in vitro, with IC50 values between 0.29-0.52 μM. Studies indicate that Tegoprazan improves colitis and enhances intestinal epithelial barrier function in mice. Tegoprazan is used in research related to inflammatory bowel disease, gastric acid-related conditions, and motility impairments.

References : Son M. et al.: Front Immunol.,13, 870817, 2022; Kim D. K, et al.: J. Pharmacol Exp Ther., 369(3), 318-327, 2019; Takahashi N. et al.: J. Pharmacol Exp Ther., 364(2), 275-286, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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