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Telotristat

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SI-5455

Telotristat, >98% (HPLC)

CAS No. : [1033805-28-5]

MDL No. : MFCD20528907

Synonyms : LP-778902

IUPAC Name : (S)-2-Amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid

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Chemical Properites
Mol. Formula :
C25H22ClF3N6O3
Mol. Weight :
546.94
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Telotristat is a potent tryptophan hydroxylase (TPH) inhibitor with an in vivo IC50 of 0.028 μM. Telotristat can be used for the treatment of refractory carcinoid syndrome diarrhea in combination with somatostatin analog (SSA).

References : Lapuerta P. et al.: Clin. Invest. (Lond.) 5(5), 447-456, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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