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Temozolomide-d3

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SL-11691

Temozolomide-d3, >98%

CAS No. : [208107-14-6]

Synonyms : NSC 362856-d3; CCRG 81045-d3; TMZ-d3

IUPAC Name : 3-(Methyl-d3)-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

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Chemical Properites
Mol. Formula :
C6H3D3N6O2
Mol. Weight :
197.17
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Temozolomide-d3 is a deuterium-labelled version of Temozolomide. This can be used as an analytical labelled reference standard. Temozolomide is an oral active DNA alkylating agent that crosses the blood-brain barrier and induces autophagy and apoptosis. It is effective against tumors with low O6-alkylguanine DNA alkyltransferase and intact mismatch repair, exhibiting both antitumor and antiangiogenic properties.

References : Tentori L. et al.: Blood, 99(6), 2241-4, 2002; Mathieu V. et al.: Neoplasia, 10(12), 1383-92, 2008; Perazzoli G. et al.: PLoS One 10(10), e0140131, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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