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Tenofovir alafenamide methyl ester (mixture of diastereomers)

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Tenofovir alafenamide methyl ester (mixture of diastereomers), >98%

CAS No. : [342631-31-6]

Synonyms : Tenofovir impurity 37

IUPAC Name : Methyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate

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Chemical Properites
Mol. Formula :
C19H25N6O5P
Mol. Weight :
448.42
Appearance :
Off-white solid (hygroscopic)
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Tenofovir alafenamide, which is a prodrug of Tenofovir. It is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.

References : Murphy R. A. et al. Int. J. Mol. Sci.18(3), 2017; Musumeci G. et al. Sci. Rep. 7, 41018, 2017; Wahl A. et al. Sci. Rep.7, 41098, 2017; Menne S. et al.: J. Antimicrob Agents Chemother., 49(7), 2720-2728, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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