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Teplinovivint

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SI-7602

Teplinovivint, >98% (HPLC)

CAS No. : [1428064-91-8]

Synonyms : SM-04755

IUPAC Name : N-(6-Methoxypyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide

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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C25H26N6O2
Mol. Weight :
442.52
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Teplinovivint is a potent small‑molecule inhibitor of the Wnt signaling pathway, specifically targeting CDC-like kinase 2 (CLK2) to suppress β‑catenin–driven transcription. It demonstrates strong anti‑inflammatory and chondroprotective activity, reduces pro‑inflammatory cytokines, and promotes cartilage regeneration, making it a promising therapeutic candidate for osteoarthritis and other Wnt‑dependent degenerative diseases.

References : Sun Y. et al.: J. Med. Chem., 67(6), 4603-4623, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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