tert-Butyl (6-chloro-3-iodoimidazo[1,2-b]pyridazin-8-yl)((tetrahydro-2H-pyran-4-yl)methyl)carbamate

SI-3781

tert-Butyl (6-chloro-3-iodoimidazo[1,2-b]pyridazin-8-yl)((tetrahydro-2H-pyran-4-yl)methyl)carbamate, 97%

CAS No. : [1263425-69-9]

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Applications : This is an advanced key intermediate in the preparation of imidazo[1,2‑b]pyridazine derivatives: selective and orally available monopolar spindle 1 (Mps1) kinase inhibitors, exhibiting remarkable antiproliferative activity.

References : Kusakabe K. et al.: J. Med. Chem., 58(4), 1760-1775, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.