tert-Butyl (S)-3-(4-aminophenyl)piperidine-1-carboxylate

SL-11163

tert-Butyl (S)-3-(4-aminophenyl)piperidine-1-carboxylate, >98%

CAS No. : [1171197-20-8]

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Applications : This is an advanced key intermediate in the synthesis of Niraparib and related analogs. Niraparib is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor. Niraparib inhibits the repair of DNA damage, induces apoptosis, and demonstrates anti-tumor activity.

References : Jones P. et al.: J. Med. Chem., 52(22), 7170-85, 2009; Bridges K. A. et al.: Oncotarget., 5(13), 5076-86, 2014; Wang L. et al.: Invest New Drugs, 30(6), 2113-20, 2012; Mirza M. R. et al.: N. Engl. J. Med., 375(22), 2154-2164, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.