Tetomilast

SI-5167

Tetomilast, >98% (HPLC)

CAS No. : [145739-56-6]

MDL No. : MFCD00936868

Synonyms : OPC6535

IUPAC Name : 6-(2-(3,4-Diethoxyphenyl)thiazol-4-yl)picolinic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
1G	Request A Quote		Back Order	Estimated to ship on 04 October 2026
Note: Tetomilastis not in stock but can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and Mass analysis. Purity (HPLC) is usually >98%. COA, QC data and SDS will be provided along with the product. For information on pricing and availability please contact us at sales@syninnova.com or Request A Quote. We respond promptly. Thank You!

Applications : Tetomilast is a novel thiazole phosphodiesterase-4 (PDE-4) inhibitor, which may prove useful in both the treatment of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). The pharmacological profile of Tetomilast revealed an IC50 value of 380 nM, which is weaker than those of Roflumilast and Cilomilast. Moreover, it has a long half-life (approximately 24h) and high bioavailability (nearly 100%), which are better than those of Roflumilast and Cilomilast. These data support Tetomilast as a suitable once-daily orally administered candidate.

References : Mulhall A. M. et al.: Expert Opin. Invest. Drugs 24, 1597-1611, 2015; Ti H. et al.: J. Med. Chem., 62(13), 5944-5978, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.