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Tetramethyl N,N,O-trimethyl alendronate

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SL-4606

Tetramethyl N,N,O-trimethyl alendronate, >98%

IUPAC Name : Tetramethyl (4-(dimethylamino)-1-methoxybutane-1,1-diyl)bis(phosphonate)

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Chemical Properites
Mol. Formula :
C11H27NO7P2
Mol. Weight :
347.28
Appearance :
Oily liquid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an analog of Alendronate, which is a nitrogen-containing, second generation bisphosphonate used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.

References : Fisher J. E. et al.: Proc Natl Acad Sci U S A, 96(1), 133-138, 1999; Bergstrom J. D. et al. Arch Biochem Biophys, 373(1), 231-241, 2000; Keller R. K. et al.: Biochem Biophys Res Commun, 266(2), 560-563, 1999;Elliott S. N. et al.: Life Sci, 62(1), 77-91, 1998; Stearns M. E. et al.: Invasion Metastasis, 16(3), 116-131, 1996.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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