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TG100-115

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SI-5158

TG100-115, >98% (HPLC)

CAS No. : [677297-51-7]

MDL No. : MFCD16038873

IUPAC Name : 3,3'-(2,4-Diaminopteridine-6,7-diyl)diphenol

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Chemical Properites
Mol. Formula :
C18H14N6O2
Mol. Weight :
346.35
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : TG100-115 is a selective PI3Kγ/PI3Kδ inhibitor with IC50s of 83 and 235 nM, respectively. Also, TG100-115 can be used as a potent TRPM7 kinase inhibitor and a potent inhibitor of breast cancer cell migration.

References : Doukas J. et al. Proc Natl Acad Sci U S A. 103(52), 19866-71,2006; Song C. et al.: Biochim Biophys Acta Gen Subj., 1861(4), 947-957, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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