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TH-470

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SI-7203

TH-470, >98% (HPLC)

CAS No. : [2834739-51-2]

IUPAC Name : N-(2-(N-benzyl-4-(N-phenylsulfamoyl)benzamido)ethyl)-2-isobutyramidothiazole-5-carboxamide

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Chemical Properites
Mol. Formula :
C30H31N5O5S2
Mol. Weight :
605.73
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : TH-470 selectively inhibits LIMK1 (IC50 = 9.8 nM) and LIMK2 (IC50 = 13 nM), providing a robust chemical probe for studying LIMK‑dependent cytoskeletal regulation. Its potency and selectivity support its use in orphan disease research.

References : Hanke T. et al.: J. Med. Chem., 65(19), 13264-13287, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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