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Thioridazine

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SI-6564

Thioridazine, >98% (HPLC)

CAS No. : [50-52-2]

IUPAC Name : 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

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Chemical Properites
Mol. Formula :
C21H26N2S2
Mol. Weight :
370.57
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Thioridazine is a dopamine D2‑family receptor antagonist with potent antipsychotic and anxiolytic activity. It also inhibits PI3K–Akt–mTOR signaling with anti‑angiogenic effects and exerts antiproliferative, pro‑apoptotic activity against diverse cancer cells, selectively targeting cancer stem cells (CSCs).

References : Tschanz J. T. et, al.: Pharmacol. Biochem. Behav., 31(3), 519-22, 1988; Mu J. et, al.: Oncol. Rep., 31(5), 2107-14, 2014; Kang S. et, al.: Apoptosis, 17(9), 989-97, 2012; Loehr A. R. et, al.: Cancers (Basel), 2021; 13(9), 2045.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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