Thiorphan

SL-10029

Thiorphan, >98%

CAS No. : [76721-89-6]

IUPAC Name : (2-Benzyl-3-mercaptopropanoyl)glycine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM that competitively blocks NEP activity, preventing neuropeptide degradation such as substance P (SP) and neurokinin A (NKA). In neonatal brain injury research, Thiorphan raises SP and NKA levels, activates NK1/NK2 receptors and related pathways, inhibits overactive NMDA receptors, and protects neocortical neurons from excitotoxicity. It may also reduce NEP-driven bronchoconstriction, making it relevant for respiratory disease studies.

References : Whyteside A. R. et al.: FEBS Lett., 582(16), 2382-6, 2008; Cheung D. et al.: Am Rev Respir Dis., 145(6), 1275-80, 1992; Medja F. et al.: Brain 129(Pt 12), 3209-23, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.