THR-beta agonist 6

SI-7273

THR-β agonist 6, >98% (HPLC)

CAS No. : [2791290-58-7]

IUPAC Name : 2-(3,5-Dichloro-4-(4-isopropyl-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a pyrrolo[3,2‑b]pyridin‑5‑one–based THR‑β agonist discovered through structure‑guided design. It shows higher potency and selectivity for THR‑β over THR‑α than the clinical agent MGL‑3196, minimizing off‑target cardiac and bone effects. Notably, it achieves an exceptional liver‑to‑serum ratio of 93:1, indicating strong hepatic targeting and supporting its potential for safe, effective NASH therapy.

References : Hu L. et al.: J. Med. Chem., 66(5), 3284-3300, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.