THZ-531

SI-7822

THZ-531, >98% (HPLC)

CAS No. : [1702809-17-3]

IUPAC Name : (R,E)-N-(4-(3-((5-Chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : THZ-531 covalently inhibits CDK12 (IC₅₀ = 158 nM) and CDK13 (IC₅₀ = 69 nM), providing a selective chemical probe for dissecting transcriptional regulation, RNA‑processing programs, and DNA‑repair signaling governed by CDK12/13.

References : Zhang T. et al.: Nat. Chem. Biol., 12(10), 876-84, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.