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Ticlopidine

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SI-6599

Ticlopidine, >98% (HPLC)

CAS No. : [55142-85-3]

Synonyms : PCR-5332

IUPAC Name : 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

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Chemical Properites
Mol. Formula :
C14H14ClNS
Mol. Weight :
263.78
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Ticlopidine is an antithrombotic proagent that suppresses CD39 activity through allosteric, noncompetitive inhibition (IC₅₀ = 81.7 µM). It further inhibits NTPDase2 and NTPDase3, and demonstrates inhibitory activity toward key hepatic CYP enzymes, including CYP2C19, CYP2C9, and CYP3A4, with micromolar IC₅₀ values.

References : Laura Schäkel et al.: Arch. Pharm. (Weinheim), 354(12), e2100300, 2021; Si-hyung Yang et al.: Acta. Pharmacol. Sin., 32(7), 967-72, 2011; F. Piovella. et al.: Thromb Res., 33(3), 323-32, 1984.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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