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Tivozanib

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SI-5458

Tivozanib, >98% (HPLC)

CAS No. : [475108-18-0]

MDL No. : MFCD15146788

Synonyms : KRN951; AV-951

IUPAC Name : 1-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-3-(5-methylisoxazol-3-yl)urea

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Chemical Properites
Mol. Formula :
C22H20N4O5
Mol. Weight :
420.43
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Tivozanib is a highly potent and selective VEGFR 1/2/3 inhibitor with IC50s of 0.21, 0.16, and 0.24 nM in cell assay, respectively. Tivozanib can be used for the treatment of relapsed or refractory advanced renal cell carcinoma.

References : Nakamura K. et al.: Cancer Res., 66(18), 9134-9142, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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