TM-04-176-01

SI-6058

TM-04-176-01, >98% (HPLC)

CAS No. : [2428737-31-7]

Synonyms : PI5P4Kα-IN-1

IUPAC Name : N-(4-(5-(1H-Indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : TM-04-176-01 is a potent pan‑PI5P4K inhibitor derived from optimization of CVM‑05‑002, replacing its rhodanine‑like moiety with an indole scaffold. It shows excellent kinome‑wide selectivity, strong biochemical potency across PI5P4Kα/β/γ, and confirmed cellular target engagement in HEK293T cells via CETSA, making it a high‑quality chemical probe for PI5P4K‑driven signaling and therapeutic research.

References : Manz D. T. et al.: J. Med. Chem., 63(9), 4880-4895, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.