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TMP269

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SL-1616

TMP269, >98%

CAS No. : [1314890-29-3]

MDL No. : MFCD26522023

IUPAC Name : N-[[4-[4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide

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Chemical Properites
Mol. Formula :
C25H21F3N4O3S
Mol. Weight :
514.52
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor with IC50s of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.

References : Lobera M. et al.: Nat. Chem. Biol., 9(5), 319-25, 2013; Sinnett-Smith J. et al.: Am J Physiol Cell Physiol., 306(10), C961-971, 2014; Kikuchi S. et al.: Leukemia. 29(9),1918-1927, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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