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SI-5606

Tolrestat, >98% (HPLC)

CAS No. : [82964-04-3]

MDL No. : MFCD00864170

Synonyms : AY-27773

IUPAC Name : N-(6-Methoxy-5-(trifluoromethyl)naphthalene-1-carbonothioyl)-N-methylglycine

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Chemical Properites
Mol. Formula :
C16H14F3NO3S
Mol. Weight :
357.35
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM. Tolrestat used for the research of diabetic complications.

References : Sestanj K. et al.: J. Med Chem.. 27(3), 255-6, 1984; Simard-Duquesne N. et al.: Metabolism 34(10), 885-92, 1985; Srivastava S. et al.: Circ Res., 105(8), 793-802, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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