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Topiramate EP impurity D

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Topiramate EP impurity D, >98%

CAS No. : [950603-46-0]

Synonyms : Topiramate impurity D

IUPAC Name : ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl ((((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methoxy)carbonyl)sulfamate

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Chemical Properites
Mol. Formula :
C25H39NO15S
Mol. Weight :
625.64
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Topiramate, which is a multi-targeted inhibitor that acts on voltage-gated sodium and calcium channels, AMPA/kainate receptors, and carbonic anhydrase. Topiramate is used to treat epilepsy.

References : Taverna S. et al.: J. Pharmacol Exp Ther., 288(3), 960-968, 1999; Gryder D. S. et al.: J. Neurosci., 23(18), 7069-7074, 2003; Yang Y. et al.: Brain Res., 804(2), 169-176, 1998; Kaminski R. M. et al.: Neuropharmacology 46(8), 1097-1104, 2004; Koh S. et al.: Ann Neurol., 50(3), 366-372, 2001; Nakamura J. et al. Eur J. Pharmacol., 254(1-2), 83-89, 1994.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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