Tozasertib

SI-4883

Tozasertib, >98% (HPLC)

CAS No. : [639089-54-6]

MDL No. : MFCD13185152

Synonyms : MK-0457, VX-680

IUPAC Name : N-(4-((4-((5-Methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)thio)phenyl)cyclopropanecarboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
10MG	25.00		Back Order	Estimated to ship on 04 October 2026
25MG	45.00		Back Order	Estimated to ship on 04 October 2026
50MG	75.00		Back Order	Estimated to ship on 04 October 2026
100MG	125.00		Back Order	Estimated to ship on 04 October 2026
250MG	295.00		Back Order	Estimated to ship on 04 October 2026
500MG	496.00		Back Order	Estimated to ship on 04 October 2026
1G	855.00		Back Order	Estimated to ship on 04 October 2026

Applications : Tozasertib is a Pan-Aurora inhibitor, mostly against aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards aurora B/aurora C and 100-fold more selective for aurora A than 55 other kinases.

References : Harrington E. A. et al.: Nat Med.,10(3), 262-267, 2004; Arlot-Bonnemains Y. et al.: Endocr Relat Cancer., 15(2), 559-568, 2008; Young M.A. et al.: Cancer Res., 66(2), 1007-1014, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.