TP-060

SI-6979

TP-060, >98% (HPLC)

CAS No. : [2601393-20-6]

Synonyms : Glucosylceramide synthase-IN-1

IUPAC Name : 4-(4-Fluoro-2-(2,2,2-trifluoroethoxy)phenyl)-2-(4-(2-hydroxypropan-2-yl)phenyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : TP-060 functions as a potent and brain‑penetrant GCS inhibitor with nanomolar activity against both human (IC₅₀ = 31 nM) and mouse (IC₅₀ = 51 nM) enzymes. Its favorable pharmacological properties make it a valuable chemical probe for investigating GCS biology and Gaucher’s disease mechanisms.

References : Tanaka Y. et al.: J. Med. Chem., 65(5), 4270-4290, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.