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TPCA-1

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SI-5139

TPCA-1, >98% (HPLC)

CAS No. : [507475-17-4]

MDL No. : MFCD09037541

IUPAC Name : 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide

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Chemical Properites
Mol. Formula :
C12H10FN3O2S
Mol. Weight :
279.29
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. It is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.

References : Sachse F. et al.: Rhinology 49(2), 168-173, 2011; Nan J. et al. Mol. Cancer Ther., 13(3), 617-629, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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