TPH1 inhibitor

SI-6265

TPH1 inhibitor, >98% (HPLC)

IUPAC Name : (S)-2-Amino-3-(4-(5-(4'-hydroxy-6-methoxy-[1,1'-biphenyl]-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)propanoic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent TPH1 inhibitor (IC₅₀ = 42 nM) from the 1,2,4‑oxadiazolylphenyl alanine series, showing good liver microsomal stability and no CYP or hERG liabilities. It selectively inhibits peripheral TPH1 with limited BBB penetration. In high‑fat‑diet mice, it reduces body‑weight gain, body fat, and hepatic lipid accumulation, while improving glucose intolerance and energy expenditure, making it a promising therapeutic lead for obesity and fatty liver disease.

References : Bae J. E. et al.: J. Med. Chem., 64(2), 1037−1053, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.