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trans-AUCB

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SI-5491

trans-AUCB, >98% (HPLC)

CAS No. : [885012-33-9]

IUPAC Name : 4-(((1R,4r)-4-(3-((3S,5S,7S)-Adamantan-1-yl)ureido)cyclohexyl)oxy)benzoic acid

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Chemical Properites
Mol. Formula :
C24H32N2O4
Mol. Weight :
412.53
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : trans-AUCB (t-AUCB) is a potent, orally active and selective soluble epoxide hydrolase (sEH) inhibitor with IC50s of 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively. trans-AUCB has antiglioma activity.

References : Li J. et al.: J. Neurooncol., 108(3), 385-93, 2012; Liu J. Y. et al.: Br. J. Pharmacol., 156(2), 284-96, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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