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trans-Carboxy glimepirid-d5

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SL-5766

trans-Carboxy glimepirid-d5, >98%

CAS No. : [1217718-14-3]

IUPAC Name : (1r,4r)-4-(3-((4-(2-(3-(Ethyl-d5)-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamido)ethyl)phenyl)sulfonyl)ureido)cyclohexane-1-carboxylic acid

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Chemical Properites
Mol. Formula :
C24H27D5N4O7S
Mol. Weight :
525.63
Appearance :
White to Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an active deuterium labelled version metabolite of Glimepiride, which is a potent Kir6.2/SUR inhibitor, belongs to the sulfonylurea class of drug, used in the treatment of type 2 diabetes mellitus.

References : Song D. K. et al.: Br. J. Pharmacol., 133(1), 193-199, 2001; Müller G. et al.: Horm Metab Res., 28(9), 469-487, 1996; Lawrence C. L. et al.: Br. J. Pharmacol., 136(5), 746-752, 2002; Rabbani S. I. et al.: Indian J. Exp Biol., 47(10), 804-810, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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