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trans-Doxercalciferol

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trans-Doxercalciferol, >98%

CAS No. : [74007-20-8]

IUPAC Name : (1R,3S,E)-5-(2-((1R,7aR,E)-1-((2R,5R,E)-5,6-Dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol

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Chemical Properites
Mol. Formula :
C28H44O2
Mol. Weight :
412.66
Appearance :
White to Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : trans-Doxercalciferol is an analog of Doxercalciferol, which is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion. It is used to treat secondary hyperparathyroidism and metabolic bone disease.

References : St-Arnaud R. et al.: Nephron Exp Nephrol.,119(3), e67-74, 2011; Choi J. H. et al.: J. Card Fail., 17(12), 1051-1058, 2011; Wang X. X. et al.: Am J. Physiol Renal Physiol., 300(3), F801-810, 2011; Zhang Y. et al. Am J. Physiol Renal Physiol., 297(3), F791-801, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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