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Traxoprodil mesylate

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SI-7617

Traxoprodil mesylate, >98% (HPLC)

CAS No. : [188591-67-5]

Synonyms : CP-101606 mesylate

IUPAC Name : 1-((1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol methanesulfonate

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Chemical Properites
Mol. Formula :
C20H25NO3 • CH3SO2OH
Mol. Weight :
423.52
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Traxoprodil mesylate selectively inhibits NMDA receptor activity and confers robust neuroprotection in hippocampal neurons, with an IC50 of 10 nM. It is widely used to investigate NR2B‑dependent signaling and excitotoxic mechanisms.

References : Chenard B. L. et al.: J. Med. Chem., 38(16), 3138-45, 1995; Poleszak E. et al.: Metab. Brain Dis., 31(4), 803-14, 2016; Naspolini A. P. et al.: Epilepsy Res., 100(1-2),12-9, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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